PHARMACOKINETIC OF CEFTIOFUR SODIUM IN KANKREJ COW CALVES FOLLOWING A SINGLE INTRAMUSCULAR INJECTION

M.B. SOLANKI¹*, H.B. PATEL², S.K. MODI³, R.D. SINGH⁴, V.N. SARVAIYA⁵, T.D. GHULE⁶, B.R. TARAL^7
1Department of Veterinary Pharmacology & Toxicology, College of Veterinary Science & Animal Husbandry, Sardarkrushinagar, 385505, Kamdhenu University, Gandhinagar, 382010, Gujarat, India
²Department of Veterinary Pharmacology & Toxicology, College of Veterinary Science & Animal Husbandry, Sardarkrushinagar, 385505, Kamdhenu University, Gandhinagar, 382010, Gujarat, India
³Department of Veterinary Pharmacology & Toxicology, College of Veterinary Science & Animal Husbandry, Sardarkrushinagar, 385505, Kamdhenu University, Gandhinagar, 382010, Gujarat, India
⁴Department of Veterinary Pharmacology & Toxicology, College of Veterinary Science & Animal Husbandry, Sardarkrushinagar, 385505, Kamdhenu University, Gandhinagar, 382010, Gujarat, India
⁵Department of Veterinary Pharmacology & Toxicology, College of Veterinary Science & Animal Husbandry, Sardarkrushinagar, 385505, Kamdhenu University, Gandhinagar, 382010, Gujarat, India
⁶Department of Veterinary Pharmacology & Toxicology, College of Veterinary Science & Animal Husbandry, Sardarkrushinagar, 385505, Kamdhenu University, Gandhinagar, 382010, Gujarat, India
⁷Department of Livestock Products Technology, College of Veterinary Science and Animal Husbandry, Anand, 388001, Kamdhenu University, Gandhinagar, 382010, Gujarat, India
* Corresponding Author : solankimittal82@gmail.com

Received : 08-11-2022     Accepted : 28-11-2022     Published : 30-11-2022
Volume : 14     Issue : 11       Pages : 11911 - 11913
Int J Agr Sci 14.11 (2022):11911-11913

Keywords : Sodium, Intramuscular Route, Non-Compartment, Pharmacokinetics
Conflict of Interest : None declared
Acknowledgements/Funding : Authors are thankful to Department of Veterinary Pharmacology & Toxicology, Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Dantiwada, 385506, Kamdhenu University, Gandhinagar, 382010, Gujarat, India and Department of Livestock Products Technology, College of Veterinary Science and Animal Husbandry, Anand, 388001, Kamdhenu University, Gandhinagar, 382010, Gujarat, India
Author Contribution : All authors equally contributed

The present investigation on pharmacokinetics of the ceftiofur alone (following intramuscular administration) in six healthy Kankrej cow calves @ 4.4 mg/kg was conducted to explore the disposition and arrive at the clinically effective dosage regimens. The blood samples were collected at predetermined intervals following drug administration in cow calves and plasma was separated for quantification of ceftiofur by UHPLC with UV detector. The concentration vs time data were analyzed using PK 2.0 Solver software with non-compartment approach. Following IM administration of ceftiofur alone, the drug was detected for up to 24 h with last concentrations of 0.59 µg/ml, A peak ceftiofur (alone) concentration (Cmax) by intramuscular route was observed as 11.45 µg/ml at 45 min of drug administration. After administration of ceftiofur alone @ 4.4 mg/Kg intramuscularly in cow calves, the value of pharmacokinetic parameters was observed ast1/2? =6.92 h, AUC = 69.40?g.h/ml, AUMC = 622.03 µg.h2/ml, MRT = 8.90 h, Vd(area) = 0.66 L/kg and ClB = 0.06 L/h/kg

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