QUANTITATIVE D-DIMER LEVELS BY A LATEX ENHANCED IMMUNOTURBIDIMETRIC TEST IN EGYPTIAN PATIENTS WITH BUDD-CHIARI SYNDROME

MOHAMED AMIN SAKR¹, MANAL FAWZY GHOZLAN², RUNIA FOUAD EL FOLLY³, HEBA HASSAN ALI⁴, NEVIEN FOUAD EL FOULY⁵*, AHMED SAMIR⁶, HAZEM EL HARIRI^7
1Tropical Medicine department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
²Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
³Tropical Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
⁴Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
⁵Health Research Department, National Center for Radiation Research and technology, Atomic Energy Authority, Cairo, Egypt
⁶Tropical Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
⁷Community Medicine department, National Research Centre, Cairo, Egypt
* Corresponding Author : novaelfouly@yahoo.com

Received : 20-01-2018     Accepted : 07-02-2018     Published : 30-03-2018
Volume : 9     Issue : 1       Pages : 369 - 371
Int J Med Clin Res 9.1 (2018):369-371

Keywords : Budd-Chiari Syndrome, D-dimer, vascular thrombosis
Conflict of Interest : None declared
Acknowledgements/Funding : Author thankful to Budd-Chiari Study Group (BCSG), Ain Shams University, Cairo, Egypt
Author Contribution : All author equally contributed

Backgrounds: Budd-Chiari Syndrome (BCS) is a hepatic venous outflow obstruction at any level between the hepatic veins and the right atrium Objective: to assess quantitative D-dimer levels in BCS cases and using it as a biomarker in diagnosis of thrombotic events. Methodology; Group I included (18) patients with primary BCS. Group II; included (22) patients with primary BCS with newly reported thrombotic event, as well as Control group. For all cases; complete lab, viral markers, thrombophilia work up, D-dimer level assessment as well as radiological evaluation were done. Results: Assessment of D-dimer serum levels shows a high statistical difference between the 3 studied groups (P<0.01). D-Dimer equals or more than to 1.65 can predict new thrombosis events with a sensitivity and specificity values (93.8% and 87.5%) respectively. Conclusion: D-dimer level was significantly higher in BCS patients on medical treatment who developed new thrombosis than patients without event of new thrombosis.

1. Zahn A, Gotthardt D, Weiss KH, Richter G, Schmidt J, Stremmel W and Sauer P. (2010) BMC Gastroenterology,10, 25.
2. Denninger M.H, Chait Y, Casadevall N, Hillaire S, Guillin MC, Bezeaud A, Erlinger S, Briere J and Valla D. (2000) Hepatology, 31(3), 587–91.
3. Ki M, Choi HY, Kim KA, Kim BH, Jang ES and Jeong SH.(2016) Liver Int., 36(7), 1067-73.
4. Murad SD, Plessier A, Hernandez-Guerra M, et al. (2009) Ann Intern Med., 151,167-175.
5. Goel RM, Johnston EL, Patel KV and Wong T. (2015) Postgrad Med J. Dec., 91(1082), 692-7.
6. Beckett D and Oliff S. (2008) Cardiovasc Intervent Radiol, 31, 839-847.
7. Copelan A, Remer EM, Sands M, Nghiem H, Kapoor B. (2015) Cardiovasc Intervent Radiol. 38(1):1-12.
8. Adam SS, Key NS and Greenberg CS (2009) Blood, 113(13), 2878–2887.
9. Legnani C, Cini M, Scarvelis D, Toulon P, Wu JR and Palareti G. (2010) Thrombosis Research; 125, 398–401.
10. Schutgens RE, Esseboom EU, Haas FJ, Nieuwenhuis HK and Biesma DH. (2002) Am J Med, 112, 617-621.
11. Gupta RT, Kakarla RK, Kirshenbaum KJ and Tapson VF (2009) AJR Am J Roentgenol, 193(2), 425-30.
12. Baglin T, Palmer CR, Luddington R, Baglin C. (2008) J Thromb Haemost, 6(4), 577-82.
13. DeLeve LD, Valla D, Garcia-Tsao G, American Association for the Study Liver Diseases (2009) Hepatology, 49(5):1729-64.
14. Janssen HL, Garcia-Pagan JC, Elias E, Mentha G, Hadengue A and Valla DC. (2003) J. Hepatol, 38, 364 -371.
15. Valla D. (2002) Semin Liver Dis., 22, 5-14.
16. Murad S D, Plessier A, Hernandez-Guerra M, Primignani M., Elias E., Bahr M., Hadengue A., Langlet P., Miranda H., Garcia Pagan J.C., Valla D.C. and Janssen H.L. (2007) J Hepatol, 46,S4.
17. Sakr M, Barakat E, Abdelhakam S, Dabbous H, Yousuf S, Shaker M and Eldorry (2011) World J Gastroenterol, 17(42), 4704-4710.
18. Mohanty D, Shetty S, Ghosh K, Pawar A and Abraham P. (2001) Hepatol, 34, 666-670.
19. Uskudar O, Akdogan M, Sasmaz N, Yilmaz S, Tola M and Sahin B. (2008) World J Gastroenterol, 14(18), 2858-2862.
20. Bargallo X, Gilabert R, Nicolau C, García-Pagán J C, Ayuso J R and Brú C. (2006) A J R, 187, 33-41.
21. Stein P, Hull RD and Patel K. (2004) Ann Intern Med, 140, 589.
22. Schrecengost J, LeGallo R, Boyd J, Moons K, Gonias S, Rose C and Bruns D. (2003) Clin Chem, 49,1483-90.
23. Righini M, Perrier A, De Moerloose P and Bounameaux H. (2008) J Thromb Haemost., 6, 1059–71.
24. Lukaschek J, Schmid HR, Vorburger C and Beer JH. (2001) Swiss Med Wkly., 131, 653–8.