ISSN : 0976-8068
EISSN : 0976-8076
S.A. SYED1, M.H. BUKHARI2, M. ALI3, R.A. WARAICH4, F.A. SYED5, A. IQBAL6, S. AMIN7
1Department of Pathology, King Edward Medical University, Lahore 54000, Pakistan.
2Department of Pathology, King Edward Medical University, Lahore 54000, Pakistan.
3Department of Pathology, King Edward Medical University, Lahore 54000, Pakistan.
4Department of Pathology, King Edward Medical University, Lahore 54000, Pakistan.
5Department of Maxi-facial Surgery, King Edward Medical University, Lahore 54000, Pakistan.
6de'Montmorency College of Dentistry, Lahore 54000, Pakistan.
7Department of Oral Biology, CMH Lahore Medical College, Lahore 54000, Pakistan.
Received : 16-08-2014 Accepted : 01-09-2014 Published : 11-09-2014
Volume : 3 Issue : 2 Pages : 80 - 84
J Pathol Res 3.2 (2014):80-84
Keywords : Argyrophilic nucleolar organizer regions, AgNOR stain, mean AgNOR, Proliferative index of AgNOR, Oral Squamous cell carcinoma
Academic Editor : Mohd Zamri Saad, Ana M. Zarate, Atosa Dorudinia, Carlos Eduardo Fonseca Alves, Dr Kanwal Saba
Conflict of Interest : Article is retracted from publication process due to co-author email
Acknowledgements/Funding : The authors are thankful for Dr Shahida Niazi for helping in our paper. They are also thankful for Professor Dr Muhammad Munir and Professor Samina Naeem for their help in using the Pathology Laboratory
Author Contribution : SAS was the principal researcher, BMH was supervisor, WRA was clinical supervisor, AM, SFA, IA and AS helped in collection of samples
Background: Oral squamous cell carcinoma (OSCC) represents the sixth most common malignant tumor in the world. The aim of this study was to detect the proliferative activity in primary oral squamous cell carcinoma by AgNOR staining. Materials and Methods: A cross sectional study was conducted on 50 cases of oral squamous cell carcinoma of Oral and Maxillofacial Surgery Department and processed for hematoxylin and eosin and AgNOR stain in the department of Pathology, King Edward Medical University. Results: Mean AgNOR (mAgNOR) count was topped up from well differentiated (3.66 ±0.58) to poorly differentiated (7.04 ± 0.65). A gradual rise of proliferative AgNOR (pAgNOR) counts was seen in different grades of OSCC, 77.45 ±4.38 in well differentiated 83.50 ±1.76 in moderately differentiated and 85.00 ±5.00 in poorly differentiated. The mAgNOR, pAgNOR, AgNOR size and distribution were significant in different grades of tumors (p < 0.05). Conclusion: Argyrophilic nucleolar organizer regions staining was helpful to compare the proliferative activity in different grades of primary oral squamous cell carcinoma.
Article is retracted from publication process due to co-author email