SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME HETEROCYCLIC COMPOUNDS WHICH CONTAINING SULFUR ATOMS

MOHAMED ABD EL-L.Z.^1
1Department of Chemistry, Faculty of Science, Damanhour University, Damanhour, Egypt.

Received : 30-11-2013     Accepted : 16-01-2014     Published : 17-07-2014
Volume : 2     Issue : 1       Pages : 26 - 30
World Res J Org Chem 2.1 (2014):26-30

Conflict of Interest : None declared

2-(substituted)-(1-(5-methylthiophen-2-yl)ethylidene)hydrazinecarbothioamide (2 and 4a,b), 2-(1-(5-methylthiophen-2-yl)ethylidene)-N-(4-oxo-5,6-dihydro-4H-1,3-thiazin-2-yl) hydrazinecarbothioamide (3) and 3-(1-(5-methylthiophen-2-yl)ethylidene)amino-2-thioxoimidazolidin-4-one (5) were synthesized via the reaction of 2-(1-(5-methylthiophen-2-yl) ethylidene)hydrazinecarbothioamide with ethyl chloroacetate, ethyl-β-chloropropionate and bromomethylheterolyl ketones under different conditions. Treatment of 5 with ethyl-β-chloropropionate, diethyl oxalate and aryl diazonium salts afforded the corresponding 1-substituted-imidazolidin-2-thione derivative (6) and 5-substituted-imidazolidin-2-thione derivatives (7 and 8). The prepared compounds also exhibited antimicrobial activity.