ESTABLISHING AN IN-SILICO AYURVEDIC MEDICATION TOWARDS REATMENT OF SCHIZOPHRENIA

Preenon Bagchi¹*, Ajit Kar², Vinobha C.S.^3
1Azyme Biosciences, Bangalore-560069
²Satsang Herbal Research Laboratory, S.R. Mandir, Satsang, Deoghar-814116
³SRM University, Chennai- 603 203
* Corresponding Author : preenonb@yahoo.com

Received : -     Accepted : -     Published : 21-12-2009
Volume : 1     Issue : 2       Pages : 46 - 50
Int J Syst Biol 1.2 (2009):46-50

Keywords : schizophrenia, drug designing, Ayurvedic medication, modelling, docking
Conflict of Interest : None declared

RGS4 protein responsible for Schizophrenia is taken from NCBI’s Entrez database; its 3D structure is determined by homology modelling. Ashwagandha, Sarpagandha and Mandukparni (Thankuni) were selected from Indian Ayurvedic medication. Their active component’s 3D structures were established. Their combination is found to dock with RGS4 protein, hence establishing a remedy.

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