DESIGNING AND SYNTHESIS OF SOME B-LACTAM- QUINAZOLONE COMPOUNDS FOR STUDYING THEIR ACTIVITY AGAINST ESCHERICHIA COLI AND BASCILLUS SUBTILIS

Krishna Srivastava^1
1Sri Ramswaroop Memorial College of Engg. & Mgmt., Faizabad Road Lucknow-227105

Received : -     Accepted : -     Published : 21-12-2009
Volume : 1     Issue : 2       Pages : 15 - 19
Int J Syst Biol 1.2 (2009):15-19

Keywords : Quanzolone, ı-lactam, chloroacetyl chloride, triethylamine, antharanilic acid, 1,1-biphenyl-4,4- diamine
Conflict of Interest : None declared
Acknowledgements/Funding : The authors express their sincere thanks to Prof. A.Khare,Head,Department of Chemistry, Lucknow University,Lucknow for providing Laboratory facilities.They are also thankful to the Director,CDRI,Lucknow for elemental,spectral & biological data

The synthesis of 2-Phenyl-3, 1-benzoxazine-4-one 1 have been obtained from the condensation of Antharanilic acid, acid chloride in pyridine.The compound 1 was then converted to its respective quinazolone by condensing with benzidene or Hydrazina hydrates 2or 3. Compound 2 or 3 on heating with aromatic aldehyde gave 3-(p-Arylidenoamino diphenyl)/Arylideno-amino-2-phenyl-4-(3H) quinazolone 4 or 5. Interaction of 4 or 5with chloroacetyl chloride, anhydrous ZnCl2 undergoes cyclization to give 3-(p-Arylidenoamino diphenyl)/2-Phenyl-3-{4 (-aryl)-3-chloro azetidiones)]quinazolone 7a-e and 6a-e. The new compounds have been screened for its bioevaluation against antimicrobial agents.

[1] Mich T.F. and Sanchez J.P. [U.S. Pat.1985, 4,550,104] (1986) Chem. Abstr.,104, 168455  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[2] Tripathi R.P., Singh V., Khan A.R. and Bhaduri A.P. (1995) Ind. J. Chem., 34, 791-795  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[3] Bedows E. (1982) J. Nat. Products, 45, 725- 729.  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[4] Pandey V.K., Yadav S., Chandra K. and Joshi M.N.(1999) Indian Drugs, 36, 532- 534  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[5] Onca S., Punar M. and Eraksoy H. (2004) Chemotherapy, 50, 98-100.  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[6] Duckworth D.M. and Harderz M.R. (1991) Antiviral Chem. Chemother., 2, 229  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[7] Serafinowsk A.T., Hardon M.R. and Suton D. (1995) J. Med. Chem., 38, 372  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[8] Murphy B.R. and Glasglow L.A. (1970) Ann. N.Y. Acad. Sci., 173, 255  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[9] Schleifer K.H. and Kundler O. (1972) Bact. Rev., 36, 407  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[10] Bioshnoi A. Srivastava K. and Joshi M. N. (2006) Indian journal of Chemistry, 45B, 1961-1964.  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[11] Reed L. I. and Menerch H. (1938) Am J Hyg, 493  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[12] Sidweii R. A. and Huffman T. H. (1976) Appl M.icrobiol, 22, 791  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[13] Tripathi R. P., Singh V., Khan A. R. and Bhaduri A. P. (1995) Indian J Chem, 34B, 791.  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[14] Pandey V.K. and Agarwal A.K. (1979) J. Ind. Chem. Soc., 56, 706-707.  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus