EFFECTIVENESS OF MISOPROSTOL COMBINED WITH FOLEY’S CATHETER DURING SECOND TRIMESTER TERMINATION OF PREGNANCY

S. AFSHEEN¹, M.S. PIRZADO²*, F. CHANG³, S. BALOCH⁴, P. SRICHAND^5
1Department of Obstetrics and Gynaecology Unit-II Liaquat University Hospital, Hyderabad, Pakistan.
²Department of Molecular Biology and Genetics, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan.
³Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan.
⁴Medical Research Centre, Liaquat University of Medical & Health Sciences, Jamshoro, Pakistan.
⁵Department of Obstetrics and Gynaecology Unit-II Liaquat University Hospital, Hyderabad, Pakistan.
* Corresponding Author : drmspirzado@yahoo.com

Received : 12-08-2014     Accepted : 25-09-2014     Published : 30-09-2014
Volume : 3     Issue : 1       Pages : 15 - 17
World Res J Obstet Gynecol 3.1 (2014):15-17

Keywords : 2nd Trimester, Misoprostol, Foley’s catheter, Termination of pregnancy
Academic Editor : Karen Olivia Bazzo, Annekathryn Goodman, Sankhwar Pushplata, Fahmi Yassine, Magdy A Mohamed, Wael S. Nossair
Conflict of Interest : None declared

Introduction: Among the various methods of termination of pregnancies the prostaglandins are the commonly used abortificents. Misoprostol (cytotec) is recently prostaglandin E1 used for labor induction, control of postpartum hemorrhage and termination of pregnancy. The use of Foley’s catheter has been recommended in many developing countries. The reports from different countries have mentioned excellent results with the use of Foley’s catheter in combination with prostaglandins. This study concentrate on effectiveness of Misoprostol combine with Foley’s catheter. Objective: To determine the effectiveness of misoprostol combined with Foley’s Catheter during second trimester termination of pregnancy. Study Design: Case series study. Setting: Obstetrics and Gynaecology Unit-II Liaquat University Hospital, Hyderabad, Pakistan. Duration of Study: Six months from November 03, 2010 to May 02, 2011. Subjects & Methods: Total of 115 women from Out Patient Dept: in 2nd trimester of pregnancy and meet inclusion criteria were enrolled. For induction, the patient was administered 200 mcg misoprostol intra-vaginally along with passing Foley’s catheter inflated with 50 ml distilled water. The dose of misoprostol was repeated 6 hourly up to max 800 mcg until expulsion. The effectiveness of combination therapy was assessed as mentioned in operational definition. Results: Mean (±SD) age was 29.3 ± 7.8 yrs. The main indication for terminat­ion of pregnancy was intrauterine death observed in 60 (52.2%). Effectiveness of misoprostol combined with foley’s catheter for second trimester termination of pregnancy, procedure was effective in 86 (74.8%) women. Conclusion: Effectiveness of misoprostol combined with foley’s catheter for second trimester termination of pregnancy was 74.8%. High percentage of effectiveness was seen in age between 21 - 30 yrs., in gestational age > 19 weeks and in primiparous women.