IMMUNE STATUS IN CHILDREN WITH EXTRAHEPATIC PORTAL HYPERTENSION

DUBROVIN O.G.¹, PRYTULA V.P.², DZHUMA K.A.³, ZHEZHERA R.M.^4
1Department of Pediatric Surgery, Bogomolets National Medical University, Kyiv, Ukraine.
²Department of Pediatric Surgery, Bogomolets National Medical University, Kyiv, Ukraine.
³Department of Pediatric Surgery, Bogomolets National Medical University, Kyiv, Ukraine.
⁴National Specialized Pediatric Hospital, Kyiv, Ukraine.

Received : 14-11-2013     Accepted : 04-02-2014     Published : 18-06-2014
Volume : 2     Issue : 1       Pages : 45 - 48
World Res J Crit Care 2.1 (2014):45-48

The paper is focused on the features of changes in the immune system in children under the extrahepatic portal hypertension (EPH). The investigation was performed on 17 children, in whom the cell, humoral immunity and unspecific factors of immune system were evaluated. The leading pathological factors were defined. It was established that there is significant tensity in the humoral part (IgM, Ig A) and phagocytosis, secondary cell immune deficiency: decreasing of general number of lymphocytes and subpopulations of lymphocytes (CD 3+, CD4+, CD8+). Therefore, the parameters of immunogramme should be considered while monitoring such category of patients, selection of the immunocorrective therapy for prevention of postoperative complications and for the further management of extrahepatic portal hypertension.