EFFECTS OF <i>Helicobacter pylori</i> ERADICATION ON MIGRAINE TREATMENT

SEYYEDMAJIDI M.¹, BANIKARIM S.², MOSHTAGHI M.³, IRANPOUR A.⁴, EMADI B.⁵, PEIVANDI B.⁶, ROSHANDEL G.⁷, MAGHSOODLOO A.^8
1GRCGH, Golestan University of Medical Sciences, Gorgan, Iran.
²GRCGH, Golestan University of Medical Sciences, Gorgan, Iran.
³GRCGH, Golestan University of Medical Sciences, Gorgan, Iran.
⁴GRCGH, Golestan University of Medical Sciences, Gorgan, Iran.
⁵GRCGH, Golestan University of Medical Sciences, Gorgan, Iran.
⁶GRCGH, Golestan University of Medical Sciences, Gorgan, Iran.
⁷GRCGH, Golestan University of Medical Sciences, Gorgan, Iran.
⁸Department of Neurology, Golestan University of Medical Sciences, Gorgan, Iran.

Received : 14-11-2013     Accepted : 12-12-2013     Published : 30-12-2013
Volume : 1     Issue : 2       Pages : 31 - 33
World Res J Crit Care 1.2 (2013):31-33

<i>Background:</i> Association between <i>Helicobacter Pylori</i> (HP) chronic infection and migraine has been studied but the results are controversial. In this study, we aimed to evaluate the effects of HP eradication during a 1-year follow-up in a population of patients affected by migraine without aura. <i>Methods:</i> 80 consecutive HP infected patients affected by migraine without aura were enrolled in the study. Patients in 2 groups were randomly assigned using 2 different regimens; Group A: migraine treatment and a 14-day triple therapy for HP infection and Group B: migraine treatment without HP eradication. The pain duration, headache severity and the frequency of clinical headache attacks were calculated upon enrollment in the study and at 6 months and 12 months after treatment. <i>Results:</i> In group A, HP infection was eradicated in 34 of 40 patients (85%). There were significant decrease in severity and frequency (but not in duration) of the migraine attacks at 6 months (p<0.001) and a significant decrease in intensity, frequency and duration of the migraine attacks at 12 months after HP treatment in eradicated patients (p<0.001). <i>Conclusions:</i> HP might be examined in migrainous patients and eradication treatment may be beneficial for the treatment of the disease.