FORMULATION AND EVALUATION OF GLICLAZIDE LOADED ALGINATE BEADS FOR CONTROLLED RELEASE

RAO T.V.¹, BHADRAMMA N.², IMMANUELU I.³, RADHIKA M.⁴, SRINIJA⁵, SYAMALA K.^6
1Bapatla College of Pharmacy, Bapatla- 522 101, AP, India.
²Bapatla College of Pharmacy, Bapatla- 522 101, AP, India.
³Bapatla College of Pharmacy, Bapatla- 522 101, AP, India.
⁴Bapatla College of Pharmacy, Bapatla- 522 101, AP, India.
⁵Bapatla College of Pharmacy, Bapatla- 522 101, AP, India.
⁶Bapatla College of Pharmacy, Bapatla- 522 101, AP, India.

Received : 14-11-2013     Accepted : 12-12-2013     Published : 26-12-2013
Volume : 1     Issue : 2       Pages : 33 - 37
World Res J Pharmaceut Res 1.2 (2013):33-37

Microencapsulation by emulsification-ionic gelation technique is an approach to achieve controlled release of drug, gliclazide beads were designed to improve the absorption and bioavailability of the drug. Gliclazide beads were formulated with sodium alginate and by combination of sodium alginate with hydrophilic polymer such as Na CMC in the ratio of (core:coat) 1:1,1:2, 1:3, 2:1 and 3:1. The prepared beads were characterized such as particle size of beads, angle of repose by fixed funnel method, compressibility index, Hausner’s ratios, wall thickness, drug content,entrapment efficiency. The shape of beads were found to be spherical by SEM analysis. In-vitro dissolution data revealed that formulations exhibited the zero order kinetics and followed peppas transport mechanism.