Study on antiplatelets activity of Gum resins of selected Indian Medicinal Plants

Chaudhary Shaista¹*, Sharma R.C.², Rathore Mansee³, Munshi Renuka⁴, Gangawane A.K.^5
1School of Biomedical Science, Department of Biotechnology, M.G.M Institute of Health Sciences, Sec-18, Kamothe, Navi Mumbai, MS, India
²Department of Physiology, M.G.M Medical College, Sec-18, Kamothe, Navi Mumbai
³School of Biomedical Science, Department of Biotechnology, M.G.M Institute of Health Sciences, Sec-18, Kamothe, Navi Mumbai, MS, India
⁴Department of Clinical Phsrmacology, Nair Hospital and TN Medical College, Mumbai
⁵School of Biomedical Science, Department of Biotechnology, M.G.M Institute of Health Sciences, Sec-18, Kamothe, Navi Mumbai, MS, India
* Corresponding Author : drsharmax@gmail.com

Received : -     Accepted : -     Published : 15-12-2010
Volume : 1     Issue : 1       Pages : 1 - 20
Med Case Rep 1.1 (2010):1-20
DOI : http://dx.doi.org/10.9735/0976-8726.1.1.1-20

Keywords : Ayurveda, antiplatelet, Aspirin, Spirea alba and Ferula asfoetida
Conflict of Interest : None declared

Ayurveda, the ancient Indian medicine system is renowned as one of the major systems of alternative and complimentary medicine. As other herbal systems, greater parts of its medicaments are based on indigenous herbals. In the past few decades, the interest in medicinal plants has increased in a great deal because of high efficacy and low side effects. The fact that the world’s most common antiplatelet drug –Aspirin stems from a plant source Spirea alba there is a scope of developing many more drugs from plant origin producing similar effects without side effects. In the present study, we have tried to evaluate the antiplatelet properties of two most commonly used Ayurvedic plants viz. Ferula asafoetida-Hing, and Aloe vera-Kumari. Since there were many difficulties in making a clear and whole drug solution for the assay, only a part of the oleogum resin could be used for the antiplatelet study, i.e. ethanol soluble extract of Ferula asfoetida resin and water soluble extract of Aloe vera resin. However, Shorea robusta could not be studied for its antiplatelet activities as a suitable solvent was not available to dissolve the oleogum resin. The present study provides a strong basis that the oleogum resin of the two Indian Medicinal plant possess antiplatelet effects comparable to that of Aspirin and thus also provide a scope for further investigations in the related field for developing an effective yet safer antiplatelet medicine.

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