COMPARISON OF INTUBATING CONDITIONS WITH ROCURONIUM AND VECURONIUM AT SPECIFIC TIMES JUDGED BY CLINICAL CRITERIA

SATHE VISHWAS; SIVASHANKAR K.R.; SHARMA R.C.; GANGAWANE A.K.

COMPARISON OF INTUBATING CONDITIONS WITH ROCURONIUM AND VECURONIUM AT SPECIFIC TIMES JUDGED BY CLINICAL CRITERIA

SATHE VISHWAS¹*, SIVASHANKAR K.R.², SHARMA R.C.³, GANGAWANE A.K.⁴
¹Department of Anaesthesiology, M.G.M Medical College, Sec-18, Kamothe, Navi Mumbai, MS, India
²Department of Anaesthesiology, M.G.M Medical College, Sec-18, Kamothe, Navi Mumbai, MS, India
³Department of Physiology, M.G.M Medical College, Sec-18, Kamothe, Navi Mumbai, MS, India
⁴School of Biomedical Science, Department of Biotechnology, M.G.M Institute of Health Sciences, Sec-18, Kamothe, Navi Mumbai, MS, India
* Corresponding Author : vishwassathe@gmail.com

Received : - Accepted : - Published : 15-06-2010
Volume : 1 Issue : 1 Pages : 9 - 25
Neurosci Res Lett 1.1 (2010):9-25

Keywords : Vecuronium, Rocuronium, intubating and anaesthesia
Conflict of Interest : None declared

Cite - MLA : SATHE VISHWAS, et al "COMPARISON OF INTUBATING CONDITIONS WITH ROCURONIUM AND VECURONIUM AT SPECIFIC TIMES JUDGED BY CLINICAL CRITERIA." Neuroscience Research Letters 1.1 (2010):9-25.

Cite - APA : SATHE VISHWAS, SIVASHANKAR K.R., SHARMA R.C., GANGAWANE A.K. (2010). COMPARISON OF INTUBATING CONDITIONS WITH ROCURONIUM AND VECURONIUM AT SPECIFIC TIMES JUDGED BY CLINICAL CRITERIA. Neuroscience Research Letters, 1 (1), 9-25.

Cite - Chicago : SATHE VISHWAS, SIVASHANKAR K.R., SHARMA R.C., and GANGAWANE A.K. "COMPARISON OF INTUBATING CONDITIONS WITH ROCURONIUM AND VECURONIUM AT SPECIFIC TIMES JUDGED BY CLINICAL CRITERIA." Neuroscience Research Letters 1, no. 1 (2010):9-25.

Copyright : © 2010, SATHE VISHWAS, et al, Published by Bioinfo Publications. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Abstract

To compare the two non depolarizing neuromuscular blocking agent Rocuronium bromide (0.6 mg/kg body weight) and Vecuronium bromide (0.1 mg/kg body weight ) in elective surgery under general anaesthesia with respect to onset of action, intubating conditions and haemodynamic changes. It can be observed from the present study, the two groups were comparable for age, sex, weight and ASA status of the patients. Rocuronium at 0.6mg/kg bodyweight produced excellent and good intubating conditions at 95 Â±21.6 seconds and Vecuronium at 0.1mg/kg body weight produced excellent and good intubating condition at 168.0 Â±12.7 seconds after the intravenous administration. Both the drugs were comparable as regard to cardiovascular stability with the mean pulse rate was 80.10 ï‚± 06.94 and 78.53 ï‚± 08.510 per minute (p =0.4368) in Rocuronium group and Vecuronium group respectively.The mean systolic pressure was 126.20 ï‚± 08.06 mm of Hg and 129.73 ï‚± 08.27 mm of Hg (p=0.100) and the mean diastolic pressure was 86.60 ï‚± 07.70 mm of Hg and 85.80 ï‚± 07.84 mm of Hg (p= 0.691) in Rocuronium group and Vecuronium group respectively. It can be observed from above result that Rocuronium provides earlier excellent and good intubating conditions than Vecuronium with similar cardiovascular stability at intubation and post intubation period. It is evident from the above study that Rocuronium had a more rapid onset of action and provided conditions suitable for more rapid tracheal intubation than Vecuronium during general anaesthesia with endotracheal intubation in surgical patients. The haemodynamic changes in surgical patients exhibited similar trend in their variation during intubation and post intubation period in both the Rocuronium and Vecuronium groups. Thus the advantage of Rocuronium, with its early onset of action, along with good to excellent intubating conditions and the cardiovascular stability, make this neuromuscular relaxant a desirable choice for rapid tracheal intubation in surgical procedures requiring general anaesthesia with endotracheal intubation for controlled ventilation.

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