RNAI: GENE SILENCING APPROACH IN C. elegans and H. sapiens

Gomase V.S.¹*, More R.P.^2
1School of Technology, SRTM University, Sub-Center, Latur, India
²Department of Biotechnology, Shivchhatrapati College, Aurangabad, MS, India
* Corresponding Author : gomase.viren@gmail.com

Received : -     Accepted : -     Published : 15-06-2010
Volume : 1     Issue : 1       Pages : 9 - 14
Int J Mol Biol 1.1 (2010):9-14
DOI : http://dx.doi.org/10.9735/0976-0482.1.1.9-14

Conflict of Interest : None declared

siRNAs (Short interfering RNAs) and miRNAs (microRNAs), which are mediate silencing via distinct mechanisms C. elegans and Homo sapiens. The breaking of a doublestranded RNA (dsRNA) matching a specific gene sequence into short pieces called short interfering RNA, which trigger the degradation of mRNA that matches its sequence. In this review, we discussed the RNA interference with its principle and application in recent biological research areas.

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