ISSN : 0975-2927
EISSN : 0975-9166
Gomase V.S.1*, Kapoor R.A.2, Ladak S.S.3
1School of Technology, S.R.T.M. University, Sub-Centre, Latur, 413512, India
2Padmashree Dr. D.Y. Patil University, Navi Mumbai, 400614, India
3Padmashree Dr. D.Y. Patil University, Navi Mumbai, 400614, India
* Corresponding Author : Mailvirusgene1@yahoo.co.in
Received : - Accepted : - Published : 21-12-2010
Volume : 2 Issue : 2 Pages : 1 - 8
Int J Mach Intell 2.2 (2010):1-8
DOI : http://dx.doi.org/10.9735/0975-2927.2.2.1-8
Keywords : antigen protein, epitope, PSSM, SVM, MHC, peptide vaccine
Conflict of Interest : None declared
Eimeria acervulina is a species of Eimeria that causes coccidiosis in older poultry. Lesions are limited to anterior or first third of the small intestine. Peptide fragments of antigen protein can be used to select nonamers for use in rational vaccine design and to increase the understanding of roles of the immune system in infectious diseases. Analysis shows MHC class II binding peptides of antigen protein from Eimeria acervulina are important determinant for protection of host form parasitic infection. In this assay, we used PSSM and SVM algorithms for antigen design and predicted the binding affinity of antigen protein having 299 amino acids, which shows 291 nonamers. Binding ability prediction of antigen peptides to major histocompatibility complex (MHC) class I & II molecules is important in vaccine development from Eimeria acervulina.
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