Mallika R.1, Saravanan V.2
1Department of Computer Science, Sri Ramakrishna College of Arts & Science for Women, Coimbatore, India.
2Department of Computer Applications, Karunya University, Coimbatore, India
Received : - Accepted : - Published : 21-12-2009
Volume : 1 Issue : 2 Pages : 14 - 25
Int J Mach Intell 1.2 (2009):14-25
DOI : http://dx.doi.org/10.9735/0975-2927.1.2.14-25
Keywords : Support Vector Machines, Linear Discriminant Analysis, K Nearest
neighbour, Microarray data, Gene selection, Classification
Conflict of Interest : None declared
Data mining models are extensively used in the field of disease diagnosis. Gene expression data are a main factor for the success of disease diagnosis. With thousands of gene expression data, gene selection is being a big challenge prior to classification. The proposed method incorporates two stages in gene selection. In the first stage pair wise gene selection was performed using a popular statistical technique. In the second stage the gene pairs that achieved 100% Cross Validation (CV) accuracy of those genes selected in first stage were used for classification. The testing results were compared with the single stage method and improvement on the computational burden was also proven to be the best in the proposed two-stage method. The paper also compares the performances of the three different classifiers Support Vector Machines (SVM), K Nearest Neighbour (KNN), Linear Discriminant Analysis (LDA) and promising results have been achieved.
[1] Alireza Osareh, Bita Shadgar
(2009) Journal of Applied
Sciences 9(3):459-468,ISSN
1812-5654
» CrossRef » Google Scholar » PubMed » DOAJ » CAS » Scopus
[2] Andrew D. Keller, MichH
Schummer, Lee Hood, Walter L.
Ruzzo (2000), Technical
Report UW-CSE-2000-08-01
» CrossRef » Google Scholar » PubMed » DOAJ » CAS » Scopus
[3] Chih-wei Hsu and chih jen Lin
(2002) IEEE transactions on
neural networks
» CrossRef » Google Scholar » PubMed » DOAJ » CAS » Scopus
[4] Dov Stekel (2003) Microarray
Bioinformatics, Cambridge
university press, ISBN 0 521-
670500
» CrossRef » Google Scholar » PubMed » DOAJ » CAS » Scopus
[5] Dudoit, S., Fridlyand, J., &
Speed, T. (2002) Journal of the American Statistical
Association, 97, 77–87
» CrossRef » Google Scholar » PubMed » DOAJ » CAS » Scopus
[6] Elena Marchiori, Michele Sebag
(2005) Evo Workshops PP.74-
83.
» CrossRef » Google Scholar » PubMed » DOAJ » CAS » Scopus
[7] Hong Chai and Carlotta
Domeniconi (2001) Proceedings
of the Second European
Workshop on Data Mining and
Text Mining in Bioinformatics
» CrossRef » Google Scholar » PubMed » DOAJ » CAS » Scopus
[8] J. Jaeger, R. Sengupta, W.L.
Ruzzo (2003) Pacific
Symposium on Biocomputing
8:53- 64
» CrossRef » Google Scholar » PubMed » DOAJ » CAS » Scopus
[9] Juan Liu, Hitoshi Iba (2001)
Genome Informatics 12: 14–23
» CrossRef » Google Scholar » PubMed » DOAJ » CAS » Scopus
[10] Li Y., Campbell C., Tipping M.
(2002) Bioinformatics ,
18:1332-1339.
» CrossRef » Google Scholar » PubMed » DOAJ » CAS » Scopus
[11] Lipo Wang, Feng Chu, and Wei
Xie (2007) IEEE/ACM
Transactions on computational
biology and bioinformatics, vol.
4, no. 1, January-march
» CrossRef » Google Scholar » PubMed » DOAJ » CAS » Scopus
[12] Li-Yeh Chuang,Chao-Hsuan Ke,
Hsueh-Wei Chang,Cheng-hong
Yang (2009) OMICS A journal
of Integrative
Biology,Volume.13,number 2.
» CrossRef » Google Scholar » PubMed » DOAJ » CAS » Scopus
[13] Mingjun Song, Sanguthevar
Rajasekaran (2007) 21st
International Conference on
Advanced Information
Networking and Applications
workshop, IEEE
» CrossRef » Google Scholar » PubMed » DOAJ » CAS » Scopus
[14] Saravanan V., Mallika R. (2009)
International conference on e-
CASE and e-Technology.
» CrossRef » Google Scholar » PubMed » DOAJ » CAS » Scopus
[15] Saravanan V., Mallika R. (2009)
International conference on
computer engineering and
technology,IEEE
» CrossRef » Google Scholar » PubMed » DOAJ » CAS » Scopus
[16] Tibshirani R., Hastie T.,
Narasimhan B., Chu G. (2003)
Statistical Science, vol. 18, pp.
104-117
» CrossRef » Google Scholar » PubMed » DOAJ » CAS » Scopus
[17] Venu Satuluri (2007) March 15
» CrossRef » Google Scholar » PubMed » DOAJ » CAS » Scopus
[18] Yeo lee chin, Safaai Ders,
Jurnal Teknologi (D) 43 (D).
pp. 111-124. ISSN 0127-9696
» CrossRef » Google Scholar » PubMed » DOAJ » CAS » Scopus