Effect of Vitamin E on benzene induced alterations of some enzymes of carbohydrate metabolism and oxidative stress in rat liver

Ganguly S.¹*, Patra S.K.², Mandal S.K.³*
¹Department of Biological Sciences, Sankrail A. C. High School (H.S.), Sankrail, Howrah, West Bengal, India.
²Department of Physiology, Surendra Nath College, Kolkata, West Bengal, India.
³Department of Organon of Medicine, Midnapore, Homoeopathic college and Hospital, Govt. of West Bengal, Midnapore, West Bengal, India
* Corresponding Author : drsushenkmondal37@gmail.com

Received : -     Accepted : -     Published : 21-12-2010
Volume : 2     Issue : 2       Pages : 1 - 4
Int J Chem Res 2.2 (2010):1-4
DOI : http://dx.doi.org/10.9735/0975-3699.2.2.1-4

Keywords : Benzene, Vitamin E, Carbohydrate metabolism, Lipid peroxidation, antioxidant
Conflict of Interest : None declared
Acknowledgements/Funding : We wish to express our sincere gratitude to the Librarians of Indian Institute of Chemical Biology [I.I.C.B.], Kolkata; and Bose Institute, Kolkata for their continuous help in finding necessary informations regarding this study from these libraries

The effect of Vitamin E (1 mmol/kg body weight/day given intraperitoneally for 7 days before the administration of benzene) on benzene (500 mg/kg body weight/day in corn oil) induced alterations of some enzymes of carbohydrate metabolism and oxidative stress in rat liver was investigated. Control group was give only corn oil. Each treatment was carried out for 20 days. Results revealed that administration of benzene caused a significant increase in the levels of lactate dehydrogenase (LDH), Lipid peroxidation and malondialdehyde (MDA). Whereas the levels of glucose–6 phosphatase, reduced glutathione (GSH) superoxide dismutase (SOD) and Catalase were significantly decreased compared to control animals. But in those animals which received Vitamin E therapy 7 days before being challenged with benzene, the changes in those parameters were almost statistically non-significant. This study indicated that, Vitamin E, a well known antioxidant can protect the major profiles of Carbohydrate metabolism and normal oxidative state of liver from the detrimental effects of benzene at this concentration.

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